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Overview
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Ubiquitin is a protein encoded by the UBB gene which is approximately 25, 7 kDa. Ubiquitin is localised to the cytoplasm and nucleus. It is involved in CDK-mediated phosphorylation and removal of Cdc6, RET signalling, activated TLR4 signalling and signalling by Notch1. It is one of the most conserved proteins known and has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression and the stress response. Ubiquitin is expressed in the nervous system, blood, liver and pancreas. Mutations in the UBB gene may result in a cleft palate. STJ97742 was developed from clone 5F1 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous levels of ubiquitin.
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