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Overview
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The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.
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- Properties
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Overview
Immunofluorescence analysis of HeLa cells using TLR4 antibody (STJ29910) at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded rat spleen using TLR4 antibody (STJ29910) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse spleen using TLR4 antibody (STJ29910) at dilution of 1:100 (40x lens).
Western blot analysis of extracts of A-549 cells, using TLR4 antibody (STJ29910) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit.Exposure time: 5min.
Anti-TLR4 antibody
Anti-TLR4 antibody
Catalog Number:
A001037798STJ
Mfr. No.:
STJ29910
Price:
$297
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