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Overview
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TGF beta RII is a protein encoded by the TGFBR3 gene which is approximately 93, 4 kDa. TGF beta RII is secreted into the cell membrane. It is involved in apoptosis pathway, PAK pathway, CREB pathway and sertoli-sertoli cell junction dynamics. It is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. TGF beta RII is expressed in the nervous system, blood, lung, muscle and heart. Mutations in the TGFBR3 gene may result in familial cerebral saccular aneurysm and intermediate uveitis. STJ95994 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of TGF beta RIII protein.
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