Anti-TCIRG1 antibody

Catalog Number:

A001024420STJ

Mfr. No.:

STJ117577

Price:

$297

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Overview
- This gene encodes a subunit of a large protein complex known as a vacuolar H+-ATPase (V-ATPase). The protein complex acts as a pump to move protons across the membrane. This movement of protons helps regulate the pH of cells and their surrounding environment. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Alternative splicing results in multiple transcript variants. Mutations in this gene are associated with infantile malignant osteopetrosis.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human TCIRG1 (NP_006010. 2).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  V-Type Proton Atpase 116 Kda Subunit A Isoform 3; V-Atpase 116 Kda Isoform A3; Osteoclastic Proton Pump 116 Kda Subunit; Oc-116 Kda; Oc116; T-Cell Immune Regulator 1; T-Cell Immune Response Cdna7 Protein; Tirc7; Vacuolar Proton Translocating Atpase 116 Kda Subunit A Isoform 3 (Gene ID:10312; UniProt:Q13488)
  
  * For research use only