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Overview
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This gene encodes a protein localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c oxidase complex. The protein is a member of the SURF1 family, which includes the related yeast protein SHY1 and rickettsial protein RP733. The gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity, where it shares a bidirectional promoter with SURF2 on the opposite strand. Defects in this gene are a cause of Leigh syndrome, a severe neurological disorder that is commonly associated with systemic cytochrome c oxidase deficiency.
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- Properties
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Overview
Immunohistochemistry of paraffin-embedded human colon carcinoma using SURF1 antibody (STJ28841) at dilution of 1:100 (40x lens).
Western blot analysis of extracts of various cell lines, using SURF1 antibody (STJ28841) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 3s.
Anti-SURF1 antibody
Anti-SURF1 antibody
Catalog Number:
A001036906STJ
Mfr. No.:
STJ28841
Price:
$297
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