Western blot analysis of extracts from normal (control) and STK4 knockout (KO) HeLa cells, using STK4 antibody (STJ11100073) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 1s.

Anti-STK4 antibody

Catalog Number:

A001017757STJ

Mfr. No.:

STJ11100073

Price:

$295

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Overview
- The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 303-487 of human STK4 (NP_006273. 1).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Serine/Threonine-Protein Kinase 4; Mammalian Ste20-Like Protein Kinase 1; Mst-1; Ste20-Like Kinase Mst1; Serine/Threonine-Protein Kinase Krs-2 Cleaved Into-Serine/Threonine-Protein Kinase 4 37kda Subunit; Mst1/N-Serine/Threonine-Protein Kinase 4 18kda Subunit; Mst1/C (Gene ID:6789; UniProt:Q13043)
  
  * For research use only