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Overview
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Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia.
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- Properties
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Overview
Immunofluorescence analysis of mouse lung cells using SPTA1 antibody (STJ114233) at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of rat bone marrow cells using SPTA1 antibody (STJ114233) at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded mouse liver using SPTA1 antibody (STJ114233) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded rat spleen using SPTA1 antibody (STJ114233) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human tonsil using SPTA1 antibody (STJ114233) at dilution of 1:100 (40x lens).
Western blot analysis of extracts of various cell lines, using SPTA1 antibody (STJ114233) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 10s.
Anti-SPTA1 antibody
Anti-SPTA1 antibody
Catalog Number:
A001021207STJ
Mfr. No.:
STJ114233
Price:
$297
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