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Overview
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Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
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Overview
Immunohistochemistry of paraffin-embedded human prostate using SOST antibody (STJ110512) at dilution of 1:100 (40x lens).
Western blot analysis of extracts of various cell lines, using SOST antibody (STJ110512) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit._Exposure time: 30s.
Anti-SOST antibody
Anti-SOST antibody
Catalog Number:
A001017306STJ
Mfr. No.:
STJ110512
Price:
$297
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