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Overview
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Smad3 is a protein encoded by the SMAD3 gene which is approximately 48 kDa. Smad3 is localised to the cytoplasm and nucleus. It is involved in SMAD2/3 MH2 domain mutants in cancer, the cell cycle and toll-like receptor signalling pathway. It an intracellular signal transducer and transcriptional modulator activated by TGF-beta and activin type 1 receptor kinases. It binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Smad3 is expressed in the nervous system, pancreas, lung, kidney and intestine. Mutations in the SMAD3 gene may result in colorectal cancer and Loeys-Dietz syndrome. STJ95699 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Smad3 protein.
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