Name: Anti-SLPI antibody
Price: 1110.00 USD

Overview
- Recognizes secretory leukocyte proteinase inhibitor (SLPI). SLPI was identified as an alarmreactant and expression is induced by inflammatory factors like LPS, IL1 beta, TNF alpha and neutrophilselastase. SLPI is a relatively small basic antiprotease of 11.7 kDa and is a cationic non-glycosylatedprotein consisting of 107amino acids. SLPI has a high affinity for the neutrophil serine proteinases, elastase and cathepsin G. Orthologues of SLPI have been found in mice, rate, pigs and sheep. Itconsists of two highly similar WAP ('whey acid protein')/fourdisulphide core domains. SLPI contain 16cysteine residues which assemble into eight disulphide bridges (four in each WAP domain). SLPI isconstitutively expressed at many mucosal surfaces and is produced by a variety of epithelial cells, including respiratory, intestinal and amniotic epithelia. Expression is also detected in mast cells, neutrophils and macrophages. Expression of SLPI gene is significantly increased by progesterone andby the pro-inflammatory cytokines TNF-alpha and IL1-beta. Although SLPI has been shown to inhibit aspectrum of proteases (including HNE, cathepsin G, trypsin, chymotrypsin and chymase), its mainaction in this regard is likely to be the inhibition of elastase, as indicated by its low dissociationconstant and favourable kinetics of inhibition for this enzyme.Immunogen: SLPI purified from sputum
  
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Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG1
  
  Reactivity
  
  human
  
  Clone
  
  31
  
  Immunogen
  
  SLPI purified from sputum
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  100 µg purified antibody in Phosphate Buffer Saline containing 0.1% BSA and 0.02%sodium azide.
  
  Storage
  
  Store antibody at 2-8°C until expiry date. Minimise freeze-thaw cycles.
  
  Concentration
  
  100µg/ml
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Antileukoproteinase; Alp; Blpi; Husi-1; Mucus Proteinase Inhibitor; Mpi; Protease Inhibitor Wap4; Secretory Leukocyte Protease Inhibitor; Seminal Proteinase Inhibitor; Wap Four-Disulfide Core Domain Protein 4 (Gene ID:6590; UniProt:P03973)
  
  * For research use only