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Overview
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This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.
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- Properties
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Overview
Immunohistochemistry of paraffin-embedded mouse kidney using SIRT3 antibody (STJ28285) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human thyroid cancer using SIRT3 antibody (STJ28285) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded rat kidney using SIRT3 antibody (STJ28285) at dilution of 1:100 (40x lens).
![Western blot analysis of extracts of various cell lines, using [KO Validated] SIRT3 antibody (STJ28285) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 180s.](https://resource.amerigoscientific.com/p-img/STJ28285_3_WB__84814.1602786001.jpg)
Western blot analysis of extracts of various cell lines, using [KO Validated] SIRT3 antibody (STJ28285) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 180s.
![Western blot analysis of extracts of various cell lines, using [KO Validated] SIRT3 antibody (STJ28285) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 1s.](https://resource.amerigoscientific.com/p-img/STJ28285_2_WB__08420.1602786001.jpg)
Western blot analysis of extracts of various cell lines, using [KO Validated] SIRT3 antibody (STJ28285) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 1s.
![Western blot analysis of extracts of 293T cells, using [KO Validated] SIRT3 antibody (STJ28285) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 1s.](https://resource.amerigoscientific.com/p-img/STJ28285_1_WB__56448.1602786001.jpg)
Western blot analysis of extracts of 293T cells, using [KO Validated] SIRT3 antibody (STJ28285) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 1s.
Anti-SIRT3 antibody
Anti-SIRT3 antibody
Catalog Number:
A001036392STJ
Mfr. No.:
STJ28285
Price:
$295
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