Name: Anti-SIRT1 antibody
Price: 224.00 USD

Overview
- SIRT1 is a protein encoded by the SIRT1 gene which is approximately 81, 6 kDa. SIRT1 is localised to the nucleus and cytoplasm. It is involved in NAD metabolism, AMP-activated protein kinase signalling, longevity regulating pathway and p53 signalling. It is an NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy. It can also modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. SIRT1 is widely expressed in human tissues. Mutations in the SIRT1 gene may result in obesity and xeroderma pigmentosum. STJ95667 was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of SIRT1 protein.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse
  
  Immunogen
  
  Synthesized peptide derived from human SIRT1 around the non-phosphorylation site of S47.
  
  Purification
  
  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  
  Storage
  
  Store at -20°C and avoid repeat freeze-thaw cycles.
  
  Concentration
  
  1 mg/ml
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Nad-Dependent Protein Deacetylase Sirtuin-1; Hsirt1; Nad-Dependent Protein Deacylase Sirtuin-1; Regulatory Protein Sir2 Homolog 1; Sir2-Like Protein 1; Hsir2 [Cleaved Into-Sirtt1 75 Kda Fragment; 75sirt1] (Gene ID:23411; UniProt:Q96EB6)
  
  * For research use only