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Overview
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This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.
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Overview
Immunofluorescence analysis of U-2 OS cells using 43713 antibody (STJ114819) at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded rat brain using SEPT5 antibody (STJ114819) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse brain using SEPT5 antibody (STJ114819) at dilution of 1:100 (40x lens).
Western blot analysis of extracts of various cell lines, using SEPT5 antibody (STJ114819) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 30s.
Anti-SEPT5 antibody
Anti-SEPT5 antibody
Catalog Number:
A001021760STJ
Mfr. No.:
STJ114819
Price:
$297
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