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Overview
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SDF-1 is a protein encoded by the CXCL12 gene which is approximately 10, 6 kDa. SDF-1 is secreted into the extracellular space. It is involved in apoptotic pathways, PEDF induced signalling, the GPCR pathway and ERK signalling. It functions as the ligand for the G-protein coupled receptor and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumour growth and metastasis. It also acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. SDF-1 isoform alpha and beta are ubiquitously expressed with the highest levels in the liver, pancreas and spleen. Mutations in the CXCL12 gene may result in Whim syndrome. STJ95590 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of SDF-1 protein.
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