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Overview
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Members of arrestin/ beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness.
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- Properties
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Overview
Immunohistochemistry of paraffin-embedded mouse retina using SAG antibody (STJ115012) at dilution of 1:200 (40x lens).
Western blot analysis of extracts of various cell lines, using SAG antibody (STJ115012) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 90s.
Anti-SAG antibody
Anti-SAG antibody
Catalog Number:
A001021915STJ
Mfr. No.:
STJ115012
Price:
$297
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