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Overview
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This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
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- Properties
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Overview
Western blot analysis of extracts from normal (control) and RHOC knockout (KO) 293T cells, using RHOC antibody (STJ25354) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 300s.
Immunofluorescence analysis of HeLa cells using RHOC antibody (STJ25354). Blue: DAPI for nuclear staining.
Western blot analysis of extracts of various cell lines, using RHOC antibody (STJ25354).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.
Anti-RHOC antibody
Anti-RHOC antibody
Catalog Number:
A001034903STJ
Mfr. No.:
STJ25354
Price:
$295
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