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Overview
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The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
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- Properties
- Applications
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Overview
Immunofluorescence analysis of U2OS cells using Rad23B antibody (STJ29836) at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded human colon using Rad23B Rabbit pAb (STJ29836) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse testis using Rad23B Rabbit pAb (STJ29836) at dilution of 1:100 (40x lens).
Western blot analysis of extracts of various cell lines, using Rad23B antibody (STJ29836) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 90s.
Anti-RAD23B antibody
Anti-RAD23B antibody
Catalog Number:
A001037747STJ
Mfr. No.:
STJ29836
Price:
$297
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