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Overview
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This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.
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- Properties
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Overview
Immunofluorescence analysis of U-2 OS cells using PTRF antibody (STJ11100287) at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of L929 cells using PTRF antibody (STJ11100287) at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of C6 cells using PTRF antibody (STJ11100287) at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded Rat spleen using PTRF Rabbit pAb (STJ11100287) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded Human placenta using PTRF Rabbit pAb (STJ11100287) at dilution of 1:100 (40x lens).
Western blot analysis of extracts of various cell lines, using PTRF antibody (STJ11100287) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 10s.
Anti-PTRF antibody
Anti-PTRF antibody
Catalog Number:
A001017973STJ
Mfr. No.:
STJ11100287
Price:
$297
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