Western blot analysis of extracts of various cell lines, using PTPRN antibody (STJ28484) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit.Exposure time: 90s.

Anti-PTPRN antibody

Catalog Number:

A001036580STJ

Mfr. No.:

STJ28484

Price:

$297

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Overview
- The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 600-889 of human PTPRN (NP_001186693. 1).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Receptor-Type Tyrosine-Protein Phosphatase-Like N; R-Ptp-N; Islet Cell Antigen 512; Ica 512; Islet Cell Autoantigen 3; Ptp Ia-2 Cleaved Into-Ica512-N-Terminal Fragment; Ica512-Ntf-Ica512-Transmembrane Fragment; Ica512-Tmf-Ica512-Cleaved Cytosolic Fragment; Ica512-Ccf (Gene ID:5798; UniProt:Q16849)
  
  * For research use only