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Overview
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This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/ beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified.
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Overview
Immunoprecipitation analysis of 200ug extracts of A-549 cells using 3ug PSPC1 antibody (STJ116347). Western blot was performed from the immunoprecipitate using PSPC1 antibody (STJ116347) at a dilition of 1:1000.
Immunohistochemistry of paraffin-embedded Human esophageal using PSPC1 Rabbit pAb (STJ116347) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded Mouse testis using PSPC1 Rabbit pAb (STJ116347) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded Rat brain using PSPC1 Rabbit pAb (STJ116347) at dilution of 1:100 (40x lens).
Western blot analysis of extracts of various cell lines, using PSPC1 antibody (STJ116347) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 10s.
Anti-PSPC1 antibody
Anti-PSPC1 antibody
Catalog Number:
A001023206STJ
Mfr. No.:
STJ116347
Price:
$297
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