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Overview
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The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
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- Properties
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Overview
Immunohistochemistry of paraffin-embedded human colon using PSMB2 antibody (STJ115589) at dilution of 1:100 (40x lens).
Immunofluorescence analysis of MCF-7 cells using PSMB2 antibody (STJ115589). Blue: DAPI for nuclear staining.
Western blot analysis of extracts of various cell lines, using PSMB2 antibody (STJ115589) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 15s.
Anti-PSMB2 antibody
Anti-PSMB2 antibody
Catalog Number:
A001022474STJ
Mfr. No.:
STJ115589
Price:
$297
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