-
-
Overview
-
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.
Please contact us at for specific academic pricing.
-
- Properties
- Applications
-
Overview
Immunofluorescence analysis of NIH-3T3 cells using AMPKβ1 Polyclonal Antibody (STJ114365) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Western blot analysis of extracts from normal (control) and AMPKβ1 knockout (KO) HeLa cells, using AMPKβ1 antibody (STJ114365) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 5s.
Immunohistochemistry of paraffin-embedded human esophagus using AMPKβ1 antibody (STJ114365) at dilution of 1:100 (40x lens).
Western blot analysis of extracts of various cell lines, using AMPKβ1 antibody (STJ114365) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 90s.
Anti-PRKAB1 antibody
Anti-PRKAB1 antibody
Catalog Number:
A001021331STJ
Mfr. No.:
STJ114365
Price:
$295
Size:
Quantity:
Add to Cart:
.