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Overview
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PR is a protein encoded by the PGR gene which is approximately 98, 9 kDa. PR is localised to the nucleus and cytoplasm. It is involved in the oocyte meiosis, gene expression, nuclear receptor transcription pathway and signalling by ERBB4. This protein falls under the steroid receptor superfamily. It mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PR is expressed in the heart, lymph nodes, muscle, blood and nervous system. Mutations in the PGR gene may result in progesterone resistance. STJ97365 was developed from clone Z15 and was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. The antibody detects endogenous PR protein.
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