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Overview
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PPAR-alpha is a protein encoded by the PPARA gene which is approximately 52, 2 kDa. PPAR-alpha is localised to the nucleus. It is involved in regulation of cholesterol biosynthesis by SREBP, gene expression and metabolism. It is a ligand-activated transcription factor that heterodimerize with the retinoic X receptor to regulate gene expression. It is also a key regulator of lipid metabolism. PPAR-alpha is expressed in skeletal muscle, liver, heart and the kidney. Mutations in the PPARA gene may result in fatty liver disease and Tularemia. STJ95200 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of PPAR-alpha protein.
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