Anti-PPAR-Gamma antibody

Anti-PPAR-Gamma antibody

Catalog Number:
A001050571STJ
Mfr. No.:
STJ95201
Price:
$224
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      • Overview
        • PPAR-gamma is a protein encoded by the PPARG gene which is approximately 57, 6 kDa. PPAR-gamma is localised to the cytoplasm and nucleus. It is involved in regulation of lipid metabolism, gene expression, the nuclear receptor transcription pathway and AMP-activated protein kinase signalling. This protein falls under the peroxisome proliferator-activated receptor subfamily. It is a nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once logand activated, the nuclear receptor binds to DNA specific PPAR response elements and modulates the transcription of its target genes, such as acyl-CoA oxidase. PPAR-gamma has the highest expression in adipose tissue. Mutations in the PPARG gene may result in diabetes mellitus and is a cardiovascular disease risk factor. STJ95201 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of PPAR-gamma protein.

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      • Properties
        • Host
          rabbit
          Antibody Type
          polyclonal
          Isotype
          IgG
          Reactivity
          human; mouse; rat
          Immunogen
          Synthesized peptide derived from human PPAR-gamma around the non-phosphorylation site of S112.
          Purification
          The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
          Conjugate
          Unconjugated
          Formulation
          Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
          Storage
          Store at -20°C and avoid repeat freeze-thaw cycles.
          Concentration
          1 mg/ml
          Regulatory Status
          RUO
          Antigen
          Peroxisome Proliferator-Activated Receptor Gamma; Ppar-Gamma; Nuclear Receptor Subfamily 1 Group C Member 3 (Gene ID:5468; UniProt:P37231)

          * For research use only

      • Applications
        • Application
          IF; WB; IHC (paraffin); ELISA
        • Application Dilutions
          IF 1:50-200
          WB 1:500-1:2000
          IHC 1:100-1:300
          ELISA 1:10000

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