Anti-PKLR antibody

Catalog Number:

A001021017STJ

Mfr. No.:

STJ113982

Price:

$297

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Overview
- The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 446-556 of human PKLR (NP_000289. 1).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Pyruvate Kinase Pklr; Pyruvate Kinase 1; Pyruvate Kinase Isozymes L/R; R-Type/L-Type Pyruvate Kinase; Red Cell/Liver Pyruvate Kinase (Gene ID:5313; UniProt:P30613)
  
  * For research use only