Name: Anti-PI 3-kinase p11 Alpha antibody
Price: 224.00 USD

Overview
- PI 3-kinase p110 alpha is a protein encoded by the PIK3CA gene which is approximately 124, 2 kDa. PI 3-kinase p110 alpha is localised to the cytoplasm and plasma membrane. It is involved in RET signalling, downstream signalling of activated FGFR2, regulation of lipid metabolism, insulin signalling-generic cascades and development HGF signalling pathway. It is a phosphoinositide-3-kinase that generates PIP3 which plays role in recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, that activate signalling cascades involved in cell growth, survival, proliferation, motility and morphology. PI 3-kinase p110 alpha is expressed in the lung, nervous system, intestine, lymph node and kidney. Mutations in the PIK3CA gene may result in colorectal cancer and Cowden syndrome. STJ95074 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of PI 3-kinase p110 alpha protein.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse
  
  Immunogen
  
  Synthesized peptide derived from human PI 3-kinase p110alpha.
  
  Purification
  
  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  
  Storage
  
  Store at -20°C and avoid repeat freeze-thaw cycles.
  
  Concentration
  
  1 mg/ml
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Phosphatidylinositol 4-5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform; Pi3-Kinase Subunit Alpha; Pi3k-Alpha; Pi3kalpha; Ptdins-3-Kinase Subunit Alpha; Phosphatidylinositol 4-5-Bisphosphate 3-Kinase 110 Kda Catalytic Subunit Alpha; Ptdins-3-Kinase Subunit P110-Alpha; P110alpha; Phosphoinositide-3-Kinase Catalytic Alpha Polypeptide; Serine/Threonine Protein Kinase Pik3ca (Gene ID:5290; UniProt:P42336)
  
  * For research use only