Anti-Phospho-RIP2 (S176) antibody

Anti-Phospho-RIP2 (S176) antibody

Catalog Number:
A001046329STJ
Mfr. No.:
STJ90957
Price:
$224
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      • Overview
        • RIP2 is a protein encoded by the RIPK2 gene which is approximately 61, 2 kDa. RIP2 is localised to the cytoplasm. It is involved in activated TLR4 signalling, p75 NTR receptor-mediated signalling, toll-like receptor signalling pathways and cytokine signalling in immune system. It is a serine/threonine/tyrosine kinase that contains a C-terminal caspase activation and recruitment domain and plays an essential role in modulation of innate and adaptive immune responses. RIP2 is expressed in the heart, brain, placenta, lung, peripheral blood leukocytes, spleen and kidney. Mutations in the RIPK2 gene may result in x-linked lymphoproliferative syndrome and human granulocytic anaplasmosis. STJ90957 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous RIP2 protein which only binds about S176 when S176 is phosphorylated.

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      • Properties
        • Host
          rabbit
          Antibody Type
          polyclonal
          Isotype
          IgG
          Reactivity
          human; mouse
          Immunogen
          Synthesized peptide derived from human RIP2 around the phosphorylation site of S176.
          Purification
          The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
          Conjugate
          Unconjugated
          Formulation
          Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
          Storage
          Store at -20°C and avoid repeat freeze-thaw cycles.
          Concentration
          1 mg/ml
          Regulatory Status
          RUO
          Antigen
          Receptor-Interacting Serine/Threonine-Protein Kinase 2; Card-Containing Interleukin-1 Beta-Converting Enzyme-Associated Kinase; Card-Containing Il-1 Beta Ice-Kinase; Rip-Like-Interacting Clarp Kinase; Receptor-Interacting Protein 2; Rip-2; Tyrosine-Protein Kinase Ripk2 (Gene ID:8767; UniProt:O43353)

          * For research use only

      • Applications
        • Application
          WB; IHC (paraffin); ELISA
        • Application Dilutions
          WB 1:500-1:2000
          IHC 1:100-1:300
          ELISA 1:40000

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