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Overview
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c-Src is a protein encoded by the SRC gene which is approximately 59, 8 kDa. c-Src is localised to the cell membrane and mitochondria inner membrane. It is involved RET signalling, negative regulation of FGFR1 signalling, EPH-Ephrin signalling and GAB1 signalosome. It is a non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. c-Src is expressed ubiquitously. Mutations in the SRC gene result in thrombocytopenia. STJ90958 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous c-Src protein which only binds about S75 when S75 is phosphorylated.
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