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Overview
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IkappaB alpha is a protein encoded by the NFKBIA gene which is approximately 35, 6 kDa. IkappaB alpha is localised to the cytoplasm and nucleus. It is involved in activated TLR4 signalling, 4-1BB pathway and toll-like receptor signalling pathways. It inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. IkappaB alpha is expressed in adherent monocytes. Mutations in the NFKBIA gene may result in ectodermal dysplasia with T-cell immunodeficiency. STJ90311 is a synthesized peptide derived from human IkappaB-alpha around the phosphorylation site of S32/S36. This primary antibody specifically binds to endogenous IkappaB alpha protein which only binds about S23/36 when S23/36 is phosphorylated.
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