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Overview
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Peroxiredoxin 1 is a protein encoded by the PRDX1 gene which is approximately 22, 1 kDa. Peroxiredoxin 1 is localised to the cytoplasm and melanosome. It is involved in gene expression, glucose and energy metabolism and cellular senescence. This protein falls under the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. It may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8+ T-cells. It may also play a role in cancer development or progression. Peroxiredoxin 1 is expressed in the nervous system, liver, lung, skin and pancreas. Mutations in the PRDX1 gene may result in anthrax disease. STJ97014 was developed from clone 8E7 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. The antibody detects endogenous Peroxiredoxin 1 protein.
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