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Overview
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alpha-Tubulin is a protein encoded by the TUBA1A gene which is approximately 50, 1 kDa. alpha-Tubulin is localised to the cytoplasm. It is involved in the regulation of PLK1 activity at G2/M transition, development Slit-Robo signalling, the mitotic cell cycle and chaperonin-mediated protein folding. This protein falls under the tubulin family. Tubulin is the major constituent of microtubules which perform essential and diverse functions within the eukaryotic cytoskeleton. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. alpha-Tubulin is expressed at high levels in the foetal brain. Mutations in the TUBA1A gene may result in lissencephaly. STJ96937 was developed from clone 8F11 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This antibody detects endogenous alpha-Tubulin.
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