Name: Anti-Perforin antibody
Price: 358.00 USD

Overview
- Perforin is a pore‐forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis. Perforin has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non‐ specifically a variety of target cells. It is one of the main cytolytic proteins of cytolytic granules and is known to be a key effector molecule for T‐cell‐ and natural killer‐cell‐ mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. The expression of perforin is reportedly upregulated in activated CD8+ T‐cells, natural killer cells and some CD4+ T‐ cells.
  
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Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG kappa
  
  Reactivity
  
  human
  
  Clone
  
  ZM159
  
  Immunogen
  
  Recombinant human Perforin protein fragment (around aa 413‐552)
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Purified antibody diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
  
  Storage
  
  Store at 2-8°C for up to 1 year
  
  Regulatory Status
  
  RUO
  
  * For research use only