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Overview
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This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene; however, these variants have not been fully described.
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- Properties
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Overview
Immunofluorescence analysis of U2OS cells using PER1 antibody (STJ110747) at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded mouse stomach using PER1 antibody (STJ110747) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human stomach using PER1 antibody (STJ110747) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded rat kidney using PER1 antibody (STJ110747) at dilution of 1:100 (40x lens).
Western blot analysis of extracts of various cell lines, using PER1 antibody (STJ110747) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit.Exposure time: 90s.
Anti-PER1 antibody
Anti-PER1 antibody
Catalog Number:
A001017500STJ
Mfr. No.:
STJ110747
Price:
$297
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