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Overview
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PDK1 is a protein encoded by the PDPK1 gene which is approximately 63, 1 kDa. PDK1 is localised to the cytoplasm, nucleus and cell membrane. It is involved in RET signalling, IL-2 pathway, regulation of lipid metabolism and development HGF signalling pathway. It is a serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. It also plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, therefore propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage. PDK1 is expressed ubiquitously in human tissues. STJ95010 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of PDK1 protein.
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