Anti-OTUB1 antibody

Catalog Number:

A001020578STJ

Mfr. No.:

STJ113258

Price:

$297

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Overview
- The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human OTUB1 (NP_060140. 2).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Ubiquitin Thioesterase Otub1; Deubiquitinating Enzyme Otub1; Otu Domain-Containing Ubiquitin Aldehyde-Binding Protein 1; Otubain-1; Hotu1; Ubiquitin-Specific-Processing Protease Otub1 (Gene ID:55611; UniProt:Q96FW1)
  
  * For research use only