Name: Anti-NOS3 antibody
Price: 224.00 USD

Overview
- NOS3 is a protein encoded by the NOS3 gene which is approximately 133, 2 kDa. NOS3 is localised to the cell membrane, Golgi apparatus and cytoplasm. It is involved in eNOS activation and regulation, activation of cAMP-dependent PKA, arginine biosynthesis and vascular smooth muscle contraction. It is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Together with inducible nitric oxide synthase and neuronal nitric oxide synthase, it catalyses nitric oxide and L-citrulline generation from L-arginine and molecular oxygen. NOS3 is expressed in platelets, placenta, liver and kidney. Mutations in the NOS3 gene may result in Alzheimer disease and hypertension. STJ94539 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of NOS3 protein.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  Synthesized peptide derived from human NOS3 around the non-phosphorylation site of S1179.
  
  Purification
  
  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  
  Storage
  
  Store at -20°C and avoid repeat freeze-thaw cycles.
  
  Concentration
  
  1 mg/ml
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Nitric Oxide Synthase-Endothelial; Constitutive Nos; Cnos; Ec-Nos; Endothelial Nos; Enos; Nos Type III; NosIII (Gene ID:4846; UniProt:P29474)
  
  * For research use only