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Overview
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This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.
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- Properties
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Overview
Immunofluorescence analysis of HeLa cells using NF2 antibody (STJ28273). Blue: DAPI for nuclear staining.
Immunoprecipitation analysis of 200ug extracts of HeLa cells using 3ug NF2 antibody ( STJ28273). Western blot was performed from the immunoprecipitate using NF2 antibody ( STJ28273) at a dilition of 1:1000.
Western blot analysis of extracts of various cell lines, using NF2 antibody (STJ28273) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.
Anti-NF2 antibody
Anti-NF2 antibody
Catalog Number:
A001036381STJ
Mfr. No.:
STJ28273
Price:
$297
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