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Overview
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Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.
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Overview
Immunofluorescence analysis of mouse brain using NEFL Rabbit pAb (STJ24733) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Immunofluorescence analysis of rat brain using NEFL Rabbit pAb (STJ24733) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded rat brain using NEFL antibody (STJ24733) at dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded rat kidney using NEFL antibody (STJ24733) at dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded human breast cancer using NEFL antibody (STJ24733) at dilution of 1:200 (40x lens).
Western blot analysis of extracts of various cell lines, using NEFL antibody (STJ24733) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 120s.
Anti-NEFL antibody
Anti-NEFL antibody
Catalog Number:
A001034533STJ
Mfr. No.:
STJ24733
Price:
$297
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