Anti-Myogenin antibody

Anti-Myogenin antibody

Catalog Number:
IGA1029545STJ
Mfr. No.:
STJ180362
Price:
$331
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      • Overview
        • Myogenin is a member of the MyoD family of myogenic basic helix‐loop‐helix (bHLH) transcription factors that also includes MyoD, Myf‐5, and MRF4 (also known as herculinor Myf‐6). MyoD family members are expressed exclusively in skeletal muscle and play a key role in activating myogenesis by binding to enhancer sequences of muscle‐specific genes. The regulatory domain of MyoD is approximately 70 amino acids in length and includes both a basic DNA binding motif and a bHLH dimerization motif. MyoD family members share about 80% amino acid homology in their bHLH motifs. Anti‐ myogenin labels the nuclei of myoblasts in developing muscle tissue and is expressed in tumor cell nuclei of rhabdomyosarcoma and some leiomyosarcomas. Positive nuclear staining may occur in Wilms’ tumor.

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      • Properties
        • Host
          mouse
          Antibody Type
          monoclonal
          Isotype
          IgG1 kappa
          Reactivity
          human
          Clone
          ZM149
          Immunogen
          Human myogenin recombinant protein
          Conjugate
          Unconjugated
          Formulation
          Purified antibody diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
          Storage
          Store at 2-8°C for up to 1 year
          Regulatory Status
          RUO
          Antigen
          Myogenin; Class C Basic Helix-Loop-Helix Protein 3; Bhlhc3; Myogenic Factor 4; Myf-4 (Gene ID:4656; UniProt:P15173)

          * For research use only

      • Applications
        • Application
          IHC (paraffin)
        • Application Dilutions
          IHC (paraffin) 1:100‐200

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