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Overview
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Induction studies using HL-60 cells showed that BM-3 identifies a nuclear antigen which isexpressed during the early phases of myeloid differentiation, making BM-3 an early marker ofmyeloid differentiation. It is found in 98% of human granulocytes, in 80% of human monocytes andin myeloid precursor cells, residing in lymphoid and non-lymphoid tissues. It also reacts with asubset of myeloid leukemia cells. BM-3 has no reactivity with any other cell type in humantissues. In experiments using S-35 methionine labeled human myeloid leukemia cells BM-3immunoprecipitated a 13 kDa protein.Immunogen: nuclei from Pokeweed mitogen stimulated human peripheral blood lymphocytes.
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