Anti-MTHFD1 antibody

Catalog Number:

A001019215STJ

Mfr. No.:

STJ111371

Price:

$297

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Overview
- This gene encodes a protein that possesses three distinct enzymatic activities, 5, 10-methylenetetrahydrofolate dehydrogenase, 5, 10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human MTHFD1 (NP_005947. 3).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  C-1-Tetrahydrofolate Synthase-Cytoplasmic; C1-Thf Synthase Cleaved Into-C-1-Tetrahydrofolate Synthase-Cytoplasmic-N-Terminally Processed Includes-Methylenetetrahydrofolate Dehydrogenase-Methenyltetrahydrofolate Cyclohydrolase-Formyltetrahydrofolate Synthetase (Gene ID:4522; UniProt:P11586)
  
  * For research use only