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Overview
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Recognizes mouse CD34, a single-pass type I membrane glycophosphoprotein present onsmall vessel endothelial cells and hematopoietic progenitor cells. The apparent molecular mass ofCD34 is heterogeneous, depending on the glycosylation state in different cell types. In culturedendothelioma cell lysate, CD34 has a molecular weight of ~100 kDa, whereas in lung lysates it is ~80kDa. 2 Isoforms of CD34 exist, both are expressed on the cell surface.CD34 is an adhesion moleculeperforming a role in early hematopoiesis by mediating the attachment of stem cells to the bonemarrow extracellular matrix or directly to stromal cells. CD34 acts as a scaffold for the attachment oflineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or othermarrow components. CD34 presents carbohydrate ligands to selectins.
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