Name: Anti-Mouse CD272 Monoclonal Antibody ( APC Conjugated ) (0.2 mg/mL) for Flow Cytometry
Price: 251.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    CD272, also known as B and T lymphocyte attenuator (BTLA), is an Ig superfamily co-inhitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand herpes virus entry mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significantly higher expression of BTLA compared with effectors and naïve T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It was reported that BTLA may regulate T cell function by binding to B7-H4, but further studies are needed to confirm. The existence of three distinct BTLA alleles has been reported.
- Properties
  - Host
    
    rat
    
    Antibody Type
    
    monoclonal
    
    Isotype
    
    IgG1 kappa
    
    Reactivity
    
    mouse
    
    Conjugate
    
    APC
    
    Formulation
    
    PBS with 0.05% Proclin300, 1% BSA
    
    Storage
    
    Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
    
    Concentration
    
    0.2 mg/mL
    
    Antigen
    
    B- and T-lymphocyte attenuator; Btla; B- and T-lymphocyte-associated protein; CD272; Btla (Gene ID:208154; UniProt:Q7TSA3)
    
    * For research use only.
- Applications
  - Application
    
    Flow Cytometry

Anti-Mouse CD272 Monoclonal Antibody ( APC Conjugated ) (0.2 mg/mL) for Flow Cytometry

Anti-Mouse CD272 Monoclonal Antibody ( APC Conjugated ) (0.2 mg/mL) for Flow Cytometry

Background

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