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Overview
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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
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- Properties
- Applications
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Overview
Immunohistochemistry of paraffin-embedded rat kidney using MT1-MMP antibody (STJ24578) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human kidney using MT1-MMP antibody (STJ24578) at dilution of 1:100 (40x lens).
Western blot analysis of extracts of various cell lines, using MT1-MMP antibody (STJ24578) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 90s.
Anti-MMP14 antibody
Anti-MMP14 antibody
Catalog Number:
A001034441STJ
Mfr. No.:
STJ24578
Price:
$297
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