Anti-MKL1 antibody

Catalog Number:

A001021433STJ

Mfr. No.:

STJ114472

Price:

$297

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Overview
- The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human MKL1 (NP_065882. 1).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Myocardin-Related Transcription Factor A; Mrtf-A; Mkl/Myocardin-Like Protein 1; Megakaryoblastic Leukemia 1 Protein; Megakaryocytic Acute Leukemia Protein (Gene ID:57591; UniProt:Q969V6)
  
  * For research use only