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Overview
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The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants.
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Overview
Immunohistochemistry of paraffin-embedded human tonsil using MKL1 antibody (STJ110802) at dilution of 1:100 (40x lens).
Immunofluorescence analysis of U-2 OS cells using MKL1 Polyclonal Antibody (STJ110802) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Western blot analysis of extracts of various cell lines, using MKL1 antibody (STJ110802) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 10s.
Anti-MKL1 antibody
Anti-MKL1 antibody
Catalog Number:
A001017555STJ
Mfr. No.:
STJ110802
Price:
$297
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