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Overview
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The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
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Overview
Immunohistochemistry of paraffin-embedded human lung cancer using MDC1 antibody (STJ110656) at dilution of 1:100 (40x lens).
Immunofluorescence analysis of U-2 OS cells using MDC1 antibody (STJ110656) at dilution of 1:100. Blue: DAPI for nuclear staining.
Western blot analysis of extracts of various cell lines, using MDC1 antibody (STJ110656) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit._Exposure time: 5s.
Anti-MDC1 antibody
Anti-MDC1 antibody
Catalog Number:
A001017410STJ
Mfr. No.:
STJ110656
Price:
$297
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