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Overview
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The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene.
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- Properties
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Overview
Immunohistochemistry of paraffin-embedded human oophoroma using MCM3 antibody (STJ24524) at dilution of 1:100 (40x lens).
Immunofluorescence analysis of U2OS cells using MCM3 antibody (STJ24524). Blue: DAPI for nuclear staining.
Western blot analysis of extracts of various cell lines, using MCM3 antibody (STJ24524) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.
Anti-MCM3 antibody
Anti-MCM3 antibody
Catalog Number:
A001034412STJ
Mfr. No.:
STJ24524
Price:
$297
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