Name: Anti-LC3A antibody
Price: 224.00 USD

Overview
- LC3A is a protein encoded by the MAP1LC3A gene which is approximately 14, 3 kD. LC3A is localised to the cytoplasm, cytoskeleton and autophagosome. It is involved in pathways such as the autophagy pathway, pink/parkin mediated mitophagy, ferroptosis, cellular senescence and pathways affecting insulin-like growth factor-Akt signalling. MAP1A and MAP1B fall under the LC3A protein. They are microtubule-associated proteins that mediate the physical interactions between microtubules and components of the cytoskeleton. LC3A is most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes. Mutations in the LC3A gene may result in Nasu-Hakola disease, lacrimal gland adenocarcinoma and leber congenital amaurosis. STJ97755 was developed from clone 5G10. It was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. The antibody detects endogenous levels of LC3A.
  
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Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG1
  
  Reactivity
  
  human; rat; mouse
  
  Clone
  
  5G10
  
  Immunogen
  
  synthetic peptide derived from LC3A
  
  Purification
  
  The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  
  Storage
  
  Store at -20°C and avoid repeat freeze-thaw cycles.
  
  Concentration
  
  1 mg/ml
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Microtubule-Associated Proteins 1a/1b Light Chain 3a; Autophagy-Related Protein Lc3 A; Autophagy-Related Ubiquitin-Like Modifier Lc3 A; Map1 Light Chain 3-Like Protein 1; Map1a/Map1b Light Chain 3 A; Map1a/Map1b Lc3 A; Microtubule-Associated Protein 1 Light Chain 3 Alpha (Gene ID:84557; UniProt:Q9H492)
  
  * For research use only